Percentage (mean ± S.D., n = 3/group) of the harmol dose (150 nmol; ∼1.8 nmol/min/g liver) recovered as HS at the end of the 60-min mouse in situ liver perfusion
Control | GF120918 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bile | Perfusate | Liver | Bile | Perfusate | Liver | |||||||
| % | ||||||||||||
| HS | 18 ± 5 | 8 ± 1 | 10 ± 2 | 5 ± 0.4* | 19 ± 3* | 12.6 ± 0.8 | ||||||
| Recovery |
| 36 ± 5 |
|
| 37 ± 3 |
| ||||||
↵* p < 0.05, GF120918 vs. control.