Individual and mean percentages of circulating metabolites of torcetrapib in healthy male volunteers (n = 6) after oral administration of [14C]torcetrapib at a dose of 120 mg (92 μCi)
Metabolites | Total Circulating Radioactivity in Subjects | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | Mean | S.D. | ||||||||
| % | |||||||||||||||
| M3 | 2.5 | 5.3 | 7 | 12.1 | 9.6 | 6.7 | 7.2 | 3.3 | |||||||
| M4 | 66.9 | 71.5 | 63.9 | 54.4 | 67.2 | 55.3 | 63.2 | 6.9 | |||||||
| M2 | 4.5 | 2.4 | 2.5 | 3.4 | 1.5 | 4.5 | 3.1 | 1.2 | |||||||
| Torcetrapib | 26.1 | 16.2 | 21.7 | 19.1 | 12.6 | 33.5 | 21.5 | 7.5 | |||||||