TABLE 1

AUC analysis for Met-d-O, Met-l-O, total MetO, and Met in male and female hepatocytes exposed to 30 mM Met-dl-O or vehicle alone

Treatment
AUC0-1.5 h
Met-d-O
Met-l-O
MetO (total)
Met
nmol · h/106 cells nmol · h/106 cells nmol · h/106 cells nmol · h/106 cells
30 mM Met-dl-O
Male 11.8 ± 0.9a,b 59.6 ± 12.3b 71.7 ± 12.7b 1.2 ± 0.6
Female 6.9 ± 3.5 32.0 ± 13.8 38.8 ± 17.4 1.0 ± 0.5
Vehicle alone
Male 2.0 ± 0.7b 5.9 ± 3.7 7.8 ± 4.4b 0.7 ± 0.8
Female
0.0 ± 0.0
0.4 ± 0.7
0.4 ± 0.7
0.8 ± 0.9

  • ↵ a Data are expressed as mean ± S.D. (n = 3-4).

  • ↵ b Indicates values that were significantly higher than the corresponding values obtained with the opposite sex.