TABLE 2

Mean percentage cumulative recovery of radioactivity following p.o. or i.v. administration of [14C]fluticasone furoate to humans



p.o. Administration (2 mg)

i.v. Administration (0.25 mg)
Time
Feces
Urine
Total
Feces
Urine
Total
h
0-6 N.A. 0.49 0.49 N.A. 1.27 1.27
6-12 N.A. 0.69 0.69 N.A. 1.59 1.59
0-24 5.03 0.82 5.85 2.26 1.84 4.10
0-48 52.52 0.92 53.44 32.57 2.14 34.71
0-72 90.44 0.97 91.41 69.06 2.31 71.37
0-96 94.66 0.98 95.64 78.78 2.46 81.24
0-120 100.38 0.99 101.37 82.45 2.50 84.95
0-144 100.96 1.00 101.96 86.40 2.54 88.94
0-168 101.15 1.00 102.15 87.96 2.57 90.53
0-240
N.A.
N.A.
N.A.
89.78
2.61
92.39
  • N.A., not applicable.