Characteristics of control and CRF rats
Control (n = 35) | CRF (n = 35) | p Value | |
|---|---|---|---|
| Body weight (g) | 359.1 ± 6.1 | 322.0 ± 10.3 | <0.01 |
| Serum creatinine (μM) | 52.5 ± 0.9 | 189.8 ± 18.8 | <0.001 |
| Creatinine clearance (μl/100 g b.wt./min) | 323.2 ± 12.2 | 82.1 ± 8.3 | <0.001 |
| Serum urea (mM) | 5.0 ± 0.2 | 40.1 ± 5.8 | <0.001 |
Data are the mean ± S.E.M. Measurements were made at the time of sacrifice. Urinary collection was begun the day before. Blood urea and creatinine and urine creatinine were determined with an Hitachi 717 autoanalyzer (Roche Diagnostics, Basel, Switzerland)