CYP2D6 | CYP2C19 (1) | CYP2C19 (2) | CYP1A2 | pHLM | |
---|---|---|---|---|---|
Km (best fit value ± standard error) | 2.4 ± 0.6a | Km,1, 9.2 ± 5.3b | Km,2, 283 ± 163b | 1674 ± 369a | 174 ± 21a |
Vmax (best fit value ± standard error) | 0.070 ± 0.005a | Vmax,1, 0.14 ± 0.04b | Vmax,2, 0.27 ± 0.03b | 0.89 ± 0.08a | 10.4 ± 0.4a |
RAF | 0.01 | 0.01 | 0.01 | 0.16 | |
Contribution (Vmax · RAF) | 0.0007 | 0.0014 | 0.0027 | 0.143 | |
Clearance (contribution/Km) | 0.00029 | 0.00015 | 0.0000095 | 0.000085 | |
Percentage of net clearance | 54 | 28 | 2 | 16 |
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