Authors, Year | Cell Type | Blood Quantities | Number of Healthy Subjects | Phenotype | Inducing Compounds | DME and TF |
---|---|---|---|---|---|---|
ml | ||||||
Raucy et al., 1997 | Lymphocytes | 320 | 22 | Immunoblot (microsomes) | Alcohol | CYP2E1 |
RT-PCR | ||||||
Chlorzoxazone – clearance | ||||||
Baron et al., 1998 | Monocytes and culture | 10 | RT-PCR | Benzanthracene | CYP1A1, CYP1B1, CYP2B6, CYP2E1, CYP3A3/4 | |
Dexamethasone | ||||||
Immunoblot | Cyclosporine | |||||
Phenobarbital | ||||||
p-Nitrophenol hydroxylase | Tetradecanoyl-phorbol | |||||
Liposaccharide | ||||||
Dassi et al., 1998 | PBMC | ?a | 75 | RT-PCR | Tobacco | CYP1B1 |
Spencer et al., 1999 | PBMC and culture | 60 | 10 | RT-PCR | Dioxins | CYPB1 |
Stärkel et al., 1999 | Neutrophils and lymphocytes | 100 | 8 | Immunoblot | Rifampicin | CYP3A |
6βOH-cortisol | ||||||
Takeda et al., 1999 | PBMC | ? | 10 | RT-PCR Southern blot | CYP11B2 | |
Boucher et al., 2000 | PBMC | ? | 17 | Flow cytometry RT-PCR | Fat diet | CYP2E1 protein and mRNA |
Krovat et al., 2000 | PBMC | 40 | 10 | RT-PCR | CYP1A1, CYP2D6, CYP2E1, epoxide hydrolase, CYP2F1 (very low) | |
Nakamoto et al., 2000 | Lymphocytes | 10 | 8 | RT-PCR | Rifampicine 3 weeks (tuberculosis) | CYP3A4 |
Nguyen et al., 2000 | PBMC | ? | 10 | DNA arrays | Interferon | CYP4A11, CYP2J2, CYP2E1, CYP2A6, CYP1A1, CYP2B6, CYP4B1, CYP2C8, CYP3A, CYP1B1, CYP2C9, CYP2C19 |
Smart and Daly, 2000 | PBMC and culture | 20 | 30 | EROD assay | CYP1A1, AHR | |
Immunoblot | ||||||
Finnström et al., 2001 | Leucocytes | ? | 13 | RT-PCR | CYP2E1, CYP1B1, CYP1A2, CYP2E1, CYP3A4 | |
Hannon-Fletcher et al., 2001 | Lymphocytes | 15 | 8 | Immunoblot (microsomes) | (Diabetes) | CYP2E1 |
Asghar et al., 2002 | PBMC | 25 | 50 | RT-PCR | Rifampicin | CYP2C8, CYP2E1, CYP3A5, CYP3A7, CYP4A11, CYP4B11, ABCB1 |
Finnström et al., 2002 | Leucocytes | ? | 19 | RT-PCR | CYP1A2, CYP1B1, CYP2E1, CYP3A4 | |
Carcillo et al., 2003 | PBMC | 8 | 9 | Debrisoquine clearance | CYP2D6 | |
86 | RT-PCR | |||||
Gashaw et al., 2003 | Leucocytes | 8 | 96 | RT-PCR | Rifampicin 5 days | CYP3A4 |
Alprazolam clearance | ||||||
Landi et al., 2003 | PBMC and culture | 50 | 62/59 | RT-PCR | Dioxins | AHR, CYP1B1, ARNT, and CYP1A1 only after cultures |
EROD assay | ||||||
Lin et al., 2003 | PBMC and culture | 20 | 32 | RT-PCR | Benzanthracene | CYP1A1, CYP1B1, AHR, ARNT |
Tobacco | ||||||
Toide et al., 2003 | Leucocytes | 72 | RT-PCR | Dioxins | CYP1B1 | |
Tuominen et al., 2003 | PBMC | 8 | 16 | RT-PCR | Formylindolocarbazole | CYP1A1, CYP1B1 |
Furukawa et al., 2004 | Buffy coat | 10 | 20 | RT-PCR | (Cancer) | CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1 |
Lampe et al., 2004 | PBMC | 10 | 85 | Microarrays | Tobacco | CYP1B1 |
Yamamoto et al., 2004 | PBMC | ? | 13 | RT-PCR | Methylcholanthrene | CYP1A1, AHR, AHR repressor gene, ARNT |
Haas et al., 2005 | Lymphocytes | 8 | 12 | Caffeine, debrisoquine, omeprazole, midazolam clearances | Rifampicin | CYP3A4, CYP1A2, CYP2D6, CYP2C19 (very low) |
RT-PCR | ||||||
Landi et al., 2005 | PBMC and culture | 50 | 62/59 | RT-PCR | Dioxins | CYP1A1, CYP1B1 |
EROD assay | 2,3,7,8-Tetrachlorodibenzo-p-dioxin/nitrogen | |||||
Liangpunsakul et al., 2005 | PBMC | 25 | 20 | RT-PCR | Alcohol | CYP2E1, CYP3A4 |
Miura et al., 2006
| PBMC culture | ? | 7 | RT-PCR | Angiotensin II | CYP11B2 and mineralocorticoid receptor |
RT, reverse transcription; EROD, ethoxyresorufin O-de[b]ethylase
↵ a ? = not known