Comparison of kinetic parameters of sulfur and selenium compounds with purified rat renal and hepatic FMO3 Vmax and Km for the hepatic FMO3 with l-methionine and methimazole were taken from Krause et al. (1996).
Substrate | Km | Vmax | ||||
|---|---|---|---|---|---|---|
| Kidney FMO3 | Liver FMO3 | Kidney FMO3 | Liver FMO3 | |||
| mM | nmol/mg/min | |||||
| Methimazole | 0.04 | 0.01 | 101 | 168 | ||
| Seleno-l-methionine | 0.35 | 0.31 | 1148 | 1347 | ||
| l-Methionine | 2.8 | 3.4 | 253 | 261 | ||
| S-Allyl-l-cysteine | 4.3 | 5.9 | 219 | 130 | ||