Summary of pharmacokinetic parameters (plasma) for desipramine and 2-hydroxydesipramine (for both treatment patterns combined; n = 20)
Treatment | Cmax | tmax: Median (Range) | AUC | t1/2 | Cl/F | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Geometric Mean | Arithmetic Mean (S.D.) | Geometric Mean | Arithmetic Mean (S.D.) | Geometric Mean | Arithmetic Mean (S.D.) | Geometric Mean | Arithmetic Mean (S.D.) | ||||||
| ng/ml | H | ng·h/ml | h | l/h/kg | |||||||||
| Desipramine | |||||||||||||
| 50 mg desipramine | 14.7 | 16.1 (6.2) | 8.0 (4.0–16.0) | 428 | 516 (301) | 18.9 | 20.0 (7.1) | 1.5 | 1.8 (1.5) | ||||
| 50 mg desipramine + 199 mg desvenlafaxine q.d. | 17.8 | 18.6 (5.5) | 8.0 (6.0–16.0) | 528 | 594 (298) | 21.3 | 22.2 (6.4) | 1.2 | 1.3 (0.7) | ||||
| 50 mg desipramine + 30 mg duloxetine b.i.d. | 24.7 | 25.8 (7.9) | 8.0 (6.0–16.0) | 995 | 1069 (399) | 28.6 | 29.4 (7.0) | 0.6 | 0.7 (0.3) | ||||
| 2-Hydroxydesipramine | |||||||||||||
| 50 mg desipramine | 11.9 | 12.6 (4.1) | 3.0 (2.0–16.0) | 336 | 343 (69) | 20.4 | 21.5 (7.7) | ||||||
| 50 mg desipramine + 199 mg desvenlafaxine q.d. | 13.2 | 13.9 (4.5) | 7.0 (2.0–16.0) | 403 | 410 (75) | 21.5 | 22.2 (6.3) | ||||||
| 50 mg desipramine + 30 mg duloxetine b.i.d. | 8.9 | 9.5 (3.2) | 11.9 (2.0–16.0) | 430 | 437 (79) | 32.1 | 33.9 (12.9) |
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