Treatment | LSG Mean Ratio (90% Confidence Limits)b | ||||||
---|---|---|---|---|---|---|---|
Desipramine | 2-Hydroxydesipramine | ||||||
AUC (ng·h/ml) | Cmax (ng/ml) | AUC (ng·h/ml) | Cmax (ng/ml) | ||||
% | |||||||
Desipramine + 100 mg desvenlafaxine q.d. | 122 (107, 138) | 119 (108, 130) | 119 (114, 125) | 109 (100, 119) | |||
Desipramine + 30 mg duloxetine b.i.d. | 222 (195, 251) | 163 (149, 179) | 126 (120, 132) | 76 (71, 83) | |||
P valuec | <0.001 | <0.001 | 0.054 | <0.001 |