Effect of p.o. RIF on the i.v. clearance of AZI or CLARI (5 mg/kg) in the rat
CLa | Point Estimatesb | |
|---|---|---|
| ml/min/kg | unitless | |
| AZI (n = 3) | 23.2 ± 3.7 | 0.96 ± 0.25 |
| AZI + RIF regimen 2 (n = 3) | 21.9 ± 4.7 | |
| CLARI (n = 4) | 81.6 ± 10.8 | 0.94 ± 0.07 |
| CLARI + RIF regimen 2 (n = 4) | 76.0 ± 5.3 |
|
↵ a Each value represents the mean ± S.D. for the number of rats indicated next to each group
↵ b Point estimates of the clearance were determined for each individual rat in this crossover study by (AZI + p.o. RIF regimen 2)/(AZI alone) or (CLARI + p.o. RIF regimen 2)/(CLARI alone). The mean point estimate was determined by averaging and taking the S.D. of each individual rat point estimate