P450 Isoform | Percentage Change in Inhibition with Preincubation at Inhibitor Concentration [μM] | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2.06 | 4.13 | 8.25 | 16.5 | 33 | 100 | ||||||
SKF26754 | |||||||||||
CYP2B6 | +2(–35) | –6(–44) | |||||||||
CYP2C9 | +8(–37) | +6(–67) | +1(–88) | –3(–97) | |||||||
CYP2C19 | +14(–62) | +9(–79) | |||||||||
CYP2D6 | +8(–43) | +8(–74) | +9(–79) | ||||||||
CYP3A4/5 | +48(–83) | +31(–91) | +21(–93) | +5(–92) | |||||||
SKF8742 | |||||||||||
CYP2B6 | –22(–25) | –9(–39) | |||||||||
CYP2C9 | +13(–40) | +6(–67) | +4(–90) | ||||||||
CYP2C19 | –13(–63) | –13(–78) | |||||||||
CYP2D6 | –7(–60) | –3(–95) | –1(–99) | ||||||||
CYP3A4/5 | +65(–81) | +43(–92) | +38(–95) | +13(–97) | |||||||
SKF525A | |||||||||||
CYP2B6 | –1(–55) | –1(–54) | |||||||||
CYP2C9 | +8(–49/–41) | 0(–69) | –1(–89) | ||||||||
CYP2C19 | +8(–58) | +12(–74) | |||||||||
CYP2D6 | +1(–99) | 0(–100) | |||||||||
CYP3A4/5 | +64(–87) | +34(–90) | |||||||||
SKF-Acid | |||||||||||
CYP2B6 | –1(–1) | +1(1a) | |||||||||
CYP2C9 | –8(–59) | 0(–93) | 0(–100) | +1(–100) | |||||||
CYP2C19 | –6(–4) | –1(–13) | |||||||||
CYP2D6 | +4(–14) | +2(–29) | |||||||||
CYP3A4/5 | +4(–1) | +1(2a) | |||||||||
SKF-Alcohol | |||||||||||
CYP2C9 | +3(–11) | –5(–49) | |||||||||
CYP2D6 | +3(–11) | +7(–30) | |||||||||
CYP3A4/5 |
|
|
|
|
| +9(–37) |