Kinetic parameters of CLZ oxidation in individual human livers
Liver | CLZ Metabolite | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| NorCLZ | CLZ N-Oxide | ||||||||||
| Km | Vmax | Vmax/Km | Km | Vmax | Vmax/Km | ||||||
| μM | pmol/mg protein/min | pmol/mg protein/min/μmol | μM | pmol/mg protein/min | pmol/mg protein/min/μmol | ||||||
| HL12 | 54 | 597 | 11.1 | 120 | 531 | 4.43 | |||||
| HL16 | 56 | 238 | 4.25 | 109 | 665 | 6.10 | |||||
| HL22 | 56 | 396 | 7.07 | 109 | 1039 | 9.53 | |||||
| HL27 | 107 | 964 | 9.01 | 76 | 891 | 11.7 | |||||
| HL35 | 135 | 445 | 3.30 | 35 | 311 | 8.89 | |||||
| HL36 | 47 | 96 | 2.04 | 61 | 339 | 5.56 | |||||
| HL37 | 35 | 574 | 16.4 | 28 | 405 | 14.5 | |||||
| Median (range) | 56 (35–135) | 445 (96–964) | 7.07 (3.30–16.4) | 76 (28–120) | 405 (311–1039) | 8.89 (4.43–14.5) | |||||