Plasma pharmacokinetic parameters (mean ± S.D.) of total radioactivity and brivaracetam after a single 150-mg p.o. dose of 14C-brivaracetam (n = 6)
Parameter | Total Radioactivity | Brivaracetam |
|---|---|---|
| Cmax (μg/ml) | 3.6 ± 0.4 | 4.0 ± 0.5 |
| Tmax (h)a | 1.5 (0.25–2) | 1.5 (0.25–2) |
| AUC0-t (μg/ml) | 48.9 ± 7.9 | 43.4 ± 10.8 |
| AUC (μg/ml) | 49.8 ± 8.3 | 44.6 ± 11.3 |
| CL/F (ml/min/kg) | 0.77 ± 0.19 | |
| Vz/F (ml/kg) | 0.49 ± 0.05 | |
| t1/2 (h) | 8.8 ± 1.5 | 7.6 ± 1.7 |
↵ a Median (range)