Mean (S.D.) percentage cumulative recovery of total radioactivity a postdose after i.v. and p.o. administration of [14C]brasofensine in male LE rats (n = 5), male cynomolgus monkeys (n = 4), and healthy male subjects (n = 6)
Species | Matrix | i.v. Solution | p.o. Solution |
|---|---|---|---|
| Dose: 1.5 mg/kg | Dose: 4 mg/kg | ||
| Rat | Urine | 22.8 (3.8) | 21.2 (2.8) |
| Feces | 62.1 (3.3) | 71.2 (2.7) | |
| Carcassb | 5.4 (0.5) | 5.1 (0.4) | |
| Total | 90.3 (3.7) | 97.5 (0.6) | |
| Dose: 4 mg | Dose: 12 mg | ||
| Monkey | Urine | 66.8 (4.0) | 64.7 (4.0) |
| Feces | 23.4 (2.6) | 22.7 (3.8) | |
| Total | 90.2 (2.7) | 87.4 (2.9) | |
| Dose: 50 mg | |||
| Human | Urine | N.D. | 86.4 (4.5) |
| Feces | N.D. | 11.4 (2.4) | |
|
| Total | N.D. | 97.7 (2.4) |