UK-338,003 plasma pharmacokinetics after IR or MR formulations in fasted individuals All calculations for the 3-mg 9- and 15-h formulations are dose-adjusted to 1 mg. Comparisons of each MR formulation against the IR formulation for Cmax and AUC∞ were quantified as the ratio of the means expressed as a percentage and for Tmax and t1/2 as the difference in means. The 90% confidence limit is shown in parentheses.
1-mg IR Solution Fasted | 3-mg Matrix Tablet Fasted | |||||||
|---|---|---|---|---|---|---|---|---|
| 9 h | Ratio/Difference | 15 h | Ratio/Difference | |||||
| Cmax (ng/ml) | 3.89 | 2.17 | 55.6 (42.9, 65.1) | 1.21 | 31.1 (42.9, 65.1) | |||
| AUC∞(ng/h/ml) | 55.8 | 38.3 | 67.4 (53.5, 84.8) | 25.6 | 46 (36.6, 58) | |||
| Tmax (h) | 1.7 | 4.4 | 2.8 (1.7, 3.8) | 4.7 | 3.0 (2.0, 4.1) | |||
| t1/2 (h) | 14.8 | 14.2 | –0.6 (–1.3, 0.4) | 14.7 | –0.1 (–1.1, 0.5) | |||