Comparison of UK-338,003 plasma pharmacokinetics after colonic and oral administration Comparisons Cmax and AUClast were quantified as the ratio of the means expressed as a percentage and for Tmax and t1/2 as the difference in means. The 90% confidence limit is shown in parentheses.
Adjusted Means | Ratio/Difference (90% CI) | |||
|---|---|---|---|---|
| Colonic Administration | Oral Administration | |||
| Cmax (ng/ml) | 0.8 | 4.3 | 18.7% (9.4%, 37.3%) | |
| Tmax (h) | 3.1 | 1.2 | 1.89 (0.75, 3.02) | |
| AUClast (ng/h/ml) | 14.2 | 54.1 | 26.2% (14.6%, 47.2%) | |
| t1/2 (h) | 15.2 | 12.1 | 3.1 (1.33, 4.90) | |