Plasma protein-binding of [14C]bicifadine in the mouse, rat, and monkey
Concentration | Percentage Bound ± S.D.a | ||||
|---|---|---|---|---|---|
| Mouse | Rat | Monkey | |||
| 100 ng/ml | 85.7 ± 0.3 | 95.5 ± 0.2 | 95.6 ± 0.2 | ||
| 300 ng/ml | 84.8 ± 0.1 | 96.0 ± 0.2 | 96.3 ± 0.0 | ||
| 1000 ng/ml | 84.4 ± 0.1 | 96.3 ± 0.2 | 96.5 ± 0.1 | ||
| 10,000 ng/ml | 79.6 ± 0.1 | 94.8 ± 0.1 | 94.8 ± 0.3 | ||
↵ a Mean and standard deviation of three determinations.