Matrix | Mice (20 mg/kg) | Rats (20 mg/kg) | Monkeys (8 mg/kg) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | ||||||||
Intact | BDC | Intact | BDC | ||||||||||
Urine | 62.9 ± 7.8 | 71.5 ± 5.0 | 60.9 ± 3.6 | 62.4 ± 1.0 | 57.2 ± 3.6 | 65.2 ± 3.3 | 56.9 ± 5.8 | 33.0 ± 37.0 | |||||
Feces | 24.0 ± 5.9 | 12.8 ± 0.5 | 34.3 ± 2.3 | 3.4 ± 0.3 | 36.1 ± 3.0 | 2.5 ± 0.3 | 6.7 ± 1.2 | 7.3 ± 0.7 | |||||
Bile | 31.0 ± 1.2 | 30.6 ± 2.9 | |||||||||||
Cage Residue | 9.0 ± 0.2 | 8.6 ± 1.8 | 2.4 ± 0.4 | 1.9 ± 0.3 | 5.1 ± 2.6 | 1.0 ± 0.3 | 27.0 ± 3.7 | 50.9 ± 34.7 | |||||
Carcass | 0.3 ± 0.1 | 0.2 ± 0.1 | N.D. | 0.4 ± 0.0 | N.D. | 0.5 ± 0.2 | |||||||
Total | 96.2 ± 2.7 | 93.1 ± 3.0 | 97.7 ± 2.0 | 99.0 ± 0.6 | 98.4 ± 1.7 | 99.7 ± 0.6 | 90.5 ± 1.1 | 91.2 ± 3.1 |