TABLE 1

Mean pharmacokinetics of radioactivity, bicifadine, and M12 in male subjects (n = 8) administered a single oral dose of [14C]bicifadine in solution

Parameter (Units)
Plasma 14C
Blood 14C
Bicifadine
M12
Cmax (ng/ml)a 5154 ± 683 2716 ± 392 1780 ± 695 1205 ± 362
Tmax (h) 1.19 ± 0.26 1.25 ± 0.38 1.06 ± 0.42 1.50 ± 0.46
AUC0-t (ng · h/ml)a 21,413 ± 3311 11,577 ± 1822 3373 ± 1851 4641 ± 1803
AUC0-∞ (ng · h/ml) N.C. N.C. 3427 ± 1934 4697 ± 1819
t (h) 2.57 ± 0.28 2.62 ± 0.17 1.63 ± 0.56 1.83 ± 0.42
tf (h) 12.0 ± 0.0 12.0 ± 0.0 10.0 ± 2.1 13.5 ± 4.2
CL/F (l/h) N.C. N.C. 59.1 ± 23.7 N.C.
Vz/F (l)
N.C.
N.C.
125 ± 31.5
N.C.

  • N.C., not calculated; tf, time of last measurable concentration.

  • ↵ a Units for Cmax and AUC0-t of radioactivity are ng Eq/g and ng Eq · h/g.