TABLE 2

Effect of endotoxin-induced inflammation on mRNA expression of drug transporters in rodents

Transporter	Species	Tissue	Effect of Endotoxin	References
Abcb1a (Mdr1a)	Mouse	Liver	↓	Hartmann et al., 2001
		Kidney	↔	Hartmann et al., 2005
	Rat	Liver	↓	Piquette-Miller et al., 1998
		Intestine	↓	Kalitsky-Szirtes et al., 2004
		Brain	↓	Goralski et al., 2003
		Heart	↓	Wang et al., 2005
		Placenta	↓	Wang et al., 2005
Abcb1b (Mdr1b)	Mouse	Liver	↓	Hartmann et al., 2001
		Kidney	↔	Hartmann et al., 2005
	Rat	Liver	↑	Goralski et al., 2003; Wang et al., 2005
		Intestine	↔	Kalitsky-Szirtes et al., 2004
		Placenta	↓	Wang et al., 2005
		Kidney	↔	Wang et al., 2005
Abcc1 (Mrp1)	Rat	Brain	↓	Wang et al., 2005
		Placenta	↓	J. H. Wang and M. Piquette-Miller, unpublished data
Abcc2 (Mrp2)	Mouse	Liver	↓	Hartmann et al., 2002
	Rat	Liver	↓	Tang et al., 2000
		Intestine	↓	Kalitsky-Szirtes et al., 2004
		Placenta	↓	J. H. Wang and M. Piquette-Miller, unpublished data
Abcc3 (Mrp3)	Mouse	Liver	↓	Hartmann et al., 2002
	Rat	Intestine	↔	Kalitsky-Szirtes et al., 2004
		Placenta	↓	Kalitsky-Szirtes et al., 2004
Abcg2 (Brcp)	Rat	Placenta	↓	J. H. Wang and M. Piquette-Miller, unpublished data
Slc21a5 (Oatp2)	Mouse	Liver	↓	Hartmann et al., 2002
	Rat	Liver	↓	Goralski et al., 2003
		Brain	↓	Goralski et al., 2003
		Placenta	↓	J. H. Wang and M. Piquette-Miller, unpublished data