Evaluation of genes for major biological process gene ontologies and pathway analysis of genes regulated divergently by TVX (from ANOVA) between HepG2 cells and PHH for this analysis
The Panther Classification System was used (see Materials and Methods).
NCBI: Homo sapiens genes—REFLIST (25,431) | Uploaded ANOVA Genes (2025) | No. of Genes Expected | Over/Under | P | |
|---|---|---|---|---|---|
| Biological process | |||||
| Biological process unclassified | 11,321 | 423 | 728.74 | - | 1.11E-53 |
| Nucleotide and nucleic acid metabolism | 3343 | 352 | 215.19 | + | 2.81E-19 |
| Cell cycle | 1009 | 144 | 64.95 | + | 8.54E-17 |
| Protein metabolism and modification | 3040 | 305 | 195.69 | + | 1.32E-13 |
| Protein phosphorylation | 660 | 98 | 42.48 | + | 1.81E-11 |
| Protein modification | 1157 | 141 | 74.48 | + | 1.54E-10 |
| Other metabolism | 559 | 79 | 35.98 | + | 7.05E-09 |
| Cell cycle control | 418 | 64 | 26.91 | + | 8.46E-08 |
| Intracellular protein traffic | 1008 | 115 | 64.89 | + | 1.74E-07 |
| Pre-mRNA processing | 291 | 49 | 18.73 | + | 4.76E-07 |
| Sensory perception | 506 | 7 | 32.57 | - | 1.76E-06 |
| Intracellular signaling cascade | 871 | 101 | 56.07 | + | 3.29E-06 |
| Mitosis | 382 | 55 | 24.59 | + | 9.83E-06 |
| G protein-mediated signaling | 834 | 20 | 53.68 | - | 1.70E-05 |
| DNA metabolism | 360 | 51 | 23.17 | + | 4.66E-05 |
| mRNA splicing | 214 | 36 | 13.78 | + | 7.67E-05 |
| Cell adhesion-mediated signaling | 379 | 4 | 24.4 | - | 7.73E-05 |
| Stress response | 200 | 33 | 12.87 | + | 2.52E-04 |
| Cell communication | 1213 | 43 | 78.08 | - | 1.02E-03 |
| Apoptosis | 531 | 60 | 34.18 | + | 1.02E-03 |
| Lipid, fatty acid, and steroid metabolism | 770 | 79 | 49.57 | + | 1.66E-03 |
| DNA repair | 169 | 28 | 10.88 | + | 1.88E-03 |
| Carbohydrate metabolism | 592 | 64 | 38.11 | + | 2.00E-03 |
| Amino acid metabolism | 230 | 32 | 14.81 | + | 2.03E-03 |
| Oncogenesis | 472 | 53 | 30.38 | + | 3.33E-03 |
| General vesicle transport | 251 | 35 | 16.16 | + | 4.24E-03 |
| Protein folding | 186 | 28 | 11.97 | + | 7.22E-03 |
| mRNA transcription | 1914 | 167 | 123.2 | + | 7.64E-03 |
| Cell surface receptor signal transduction | 1638 | 69 | 105.44 | - | 9.35E-03 |
| Phosphate metabolism | 117 | 19 | 7.53 | + | 9.50E-03 |
| Cell adhesion | 622 | 20 | 40.04 | - | 9.82E-03 |
| Cell proliferation and differentiation | 1028 | 93 | 66.17 | + | 2.61E-02 |
| Antioxidation and free radical removal | 38 | 10 | 2.45 | + | 3.34E-02 |
| Purine metabolism | 65 | 13 | 4.18 | + | 5.90E-02 |
| Amino acid catabolism | 50 | 11 | 3.22 | + | 7.43E-02 |
| Cell structure and motility | 1148 | 99 | 73.9 | + | 7.69E-02 |
| Neuronal activities | 569 | 21 | 36.63 | - | 1.05E-01 |
| Cytokinesis | 115 | 18 | 7.4 | + | 1.31E-01 |
| Protein targeting and localization | 253 | 28 | 16.29 | + | 1.53E-01 |
| Other intracellular signaling cascade | 225 | 28 | 14.48 | + | 1.95E-01 |
| Protein targeting | 113 | 17 | 7.27 | + | 2.02E-01 |
| Endocytosis | 277 | 32 | 17.83 | + | 2.14E-01 |
| DNA replication | 155 | 21 | 9.98 | + | 2.16E-01 |
| RNA localization | 33 | 8 | 2.12 | + | 2.29E-01 |
| Pathway | |||||
| Unclassified | 22,565 | 1340 | 1452.51 | - | 2.64E-14 |
| Ubiquitin proteasome pathway | 89 | 23 | 5.73 | + | 5.75E-06 |
| PDGF signaling pathway | 189 | 32 | 12.17 | + | 2.05E-04 |
| Apoptosis signaling pathway | 131 | 25 | 8.43 | + | 3.75E-04 |
| p53 pathway | 136 | 25 | 8.75 | + | 7.07E-04 |
| FGF signaling pathway | 148 | 25 | 9.53 | + | 2.84E-03 |
| EGF receptor signaling pathway | 150 | 25 | 9.66 | + | 3.53E-03 |
| Parkinson's disease | 106 | 20 | 6.82 | + | 4.18E-03 |
| Huntington's disease | 172 | 27 | 11.07 | + | 4.72E-03 |
| T cell activation | 111 | 20 | 7.15 | + | 7.80E-03 |
| Angiogenesis | 229 | 32 | 14.74 | + | 8.45E-03 |
| Ras pathway | 91 | 17 | 5.86 | + | 1.79E-02 |
| p53 pathway feedback loops 2 | 66 | 14 | 4.25 | + | 1.93E-02 |
| Cell cycle | 29 | 9 | 1.87 | + | 1.98E-02 |
| TGF—β signaling pathway | 154 | 23 | 9.91 | + | 3.49E-02 |
| Insulin/IGF pathway—MAP kinase cascade | 49 | 10 | 3.15 | + | 2.19E-01 |
| B cell activation | 86 | 14 | 5.54 | + | 2.45E-01 |
| Oxidative stress response | 69 | 12 | 4.44 | + | 2.98E-01 |
| Toll receptor signaling pathway | 71 | 12 | 4.57 | + | 3.75E-01 |
| Circadian clock system | 16 | 5 | 1.03 | + | 5.77E-01 |
| 5—Hydroxytryptamine degradation | 17 | 5 | 1.09 | + | 7.42E-01 |
| Cholesterol biosynthesis | 11 | 4 | 0.71 | + | 8.36E-01 |
| Axon guidance mediated by netrin | 40 | 5 | 2.57 | + | 1.00E+00 |
| Axon guidance mediated by Slit/Robo | 35 | 3 | 2.25 | + | 1.00E+00 |
| Axon guidance mediated by semaphorins | 46 | 5 | 2.96 | + | 1.00E+00 |
| Alzheimer disease-presenilin pathway | 143 | 9 | 9.2 | - | 1.00E+00 |
| Alzheimer disease-amyloid secretase pathway | 77 | 3 | 4.96 | - | 1.00E+00 |
| Adrenaline and noradrenaline biosynthesis | 30 | 4 | 1.93 | + | 1.00E+00 |
| mRNA splicing | 11 | 1 | 0.71 | + | 1.00E+00 |
PDGF, platelet-derived growth factor; FGF, fibroblast growth factor; EGF, epidermal growth factor; IFG, insulin-like growth factor; TGF, transforming growth factor; MAP, mitogen-activated protein.