TABLE 1

Plasma concentrations of Org A at 2 h after a single oral administration to male Sprague-Dawley rats at various dose levels

Data are mean ± S.D.; n = 4.

Dose
Plasma Concentration
CP After CO2 Euthanasia
Jugular Vein Cannula
ng/ml
3 mg/kg 202 ± 106** 66 ± 18
5 mg/kg 437 ± 151*** 143 ± 53
10 mg/kg 866 ± 163*** 437 ± 75
30 mg/kg
3346 ± 979***
1640 ± 335

  • Statistically different from jugular vein group by one-sample t test: **P < 0.01, ***p < 0.001.