TABLE 1

Percent inhibition of active metabolite production by chemical inhibitors and isoform specific antibodies

P450 Isoform	Cycloguanil			WR99210			JPC-2067
P450 Isoform		Chemical Inhibition^a	Antibody Inhibition	Chemical Inhibition^a	Antibody Inhibition	Chemical Inhibition^a	Antibody Inhibition
			%
CYP2C19	27, 53	45	5, 43	5	N.S., 45	13
CYP3A4	47	30	45	67	62	78
CYP2D6	N.S.	10	62	44	28	28
CYP1A2	N.T.	N.S.	N.T.	N.S.	N.T.	14

N.S., not significantly inhibited; N.T., not tested.
↵ a For the inhibition of CYP2C19 with TCP, the values for both the 1.25 and 10 μM concentration are listed (1.25 μ M, 10 μM). For KTZ and QDN only the percent inhibition at the 5 μM concentration is listed.