Ro 64-0802 formation rate from oseltamivir in plasma and liver S9 from newborn and adult rats
Oseltamivir (1.5 μM) was incubated with rat plasma for 5 min and rat liver S9 fraction for 60 min at 37°C.
Source | Ro 64-0802 Formation Ratea | |||||
|---|---|---|---|---|---|---|
| pmol/min/mg protein | pmol/min/ml or g liver b | nmol/min/kg b.wt. c | ||||
| Plasma | P11 | 1.75 ± 0.32 | 87.7 ± 15.9 | 3.38 ± 0.61 | ||
| P42 | 10.6 ± 2.6 | 529 ± 129 | 20.4 ± 5.0* | |||
| Liver S9 | P11 | 0.11 ± 0.00 | 10.6 ± 0.3 | 0.42 ± 0.01 | ||
|
| P42 | 0.31 ± 0.05 | 29.7 ± 4.5 | 1.19 ± 0.18# | ||
↵* P < 0.05 statistical differences in Ro 64-0802 formation rate (nmol/min/kg) in plasma between newborn and adult rats.
↵# P < 0.05 statistical differences in Ro 64-0802 formation rate (nmol/min/kg) in liver S9 between newborn and adult rats.
↵ a Data represent means ± S.E. of three determinations using three plasma and liver S9 prepared independently from three rats.
↵ b Obtained by multiplying the value (pmol/min/mg protein) by 50.0 and 96.1 for plasma and liver S9, respectively.
↵ c Obtained by multiplying the value (pmol/min/ml plasma or g liver) by 38.5 and 40.0 for plasma and liver S9, respectively.