Mouse Liver Microsomes | DXO Formation | MEM Formation | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Km | Vmax | CLint (Vmax/Km) | Km | Vmax | CLint (Vmax/Km) | |||||||||
μM | nmol/min/mg protein | μl/min/mg protein | μM | nmol/min/mg protein | μl/min/mg protein | |||||||||
Male | 3 weeks | Wild-type | 3.80 ± 0.48 | 1.19 ± 0.03 | 313 | 237 ± 21 | 2.92 ± 0.12 | 12.3 | ||||||
Transgenic | 3.60 ± 0.34 | 3.51 ± 0.06 | 975 | 523 ± 38 | 3.85 ± 0.11 | 7.36 | ||||||||
5 weeks | Wild-type | 3.50 ± 0.46 | 1.82 ± 0.04 | 520 | 503 ± 34 | 7.68 ± 0.21 | 15.3 | |||||||
Transgenic | 3.20 ± 0.37 | 3.54 ± 0.08 | 1110 | 534 ± 41 | 7.06 ± 0.21 | 13.2 | ||||||||
8 weeks | Wild-type | 5.10 ± 0.72 | 1.17 ± 0.03 | 229 | 412 ± 52 | 2.79 ± 0.16 | 6.79 | |||||||
Transgenic | 3.10 ± 0.23 | 2.73 ± 0.03 | 880 | 374 ± 36 | 4.23 ± 0.15 | 11.3 | ||||||||
Female | 3 weeks | Wild-type | 4.40 ± 0.75 | 1.35 ± 0.04 | 307 | 552 ± 73 | 4.83 ± 0.25 | 8.75 | ||||||
Transgenic | 2.50 ± 0.27 | 2.73 ± 0.05 | 1090 | 655 ± 52 | 3.57 ± 0.11 | 5.45 | ||||||||
5 weeks | Wild-type | 3.70 ± 0.47 | 2.33 ± 0.05 | 630 | 433 ± 46 | 7.40 ± 0.28 | 17.1 | |||||||
Transgenic | 3.20 ± 0.43 | 4.71 ± 0.13 | 1470 | 500 ± 54 | 9.31 ± 0.38 | 18.6 | ||||||||
8 weeks | Wild-type | 4.30 ± 0.46 | 1.79 ± 0.03 | 416 | 354 ± 24 | 4.54 ± 0.13 | 12.8 | |||||||
|
| Transgenic | 3.00 ± 0.21 | 2.79 ± 0.03 | 930 | 412 ± 26 | 4.25 ± 0.12 | 10.3 |