Pharmacokinetic parameters calculated from total dabigatran radioactivity data
Results are presented as mean ± S.D.
5 mg of [14C]Dabigatran i.v. | 200 mg of [14C]Dabigatran Etexilate p.o. | |
|---|---|---|
| Cmax (ng/ml) | 172.0 ± 28.3 | 158.0 ± 35.0 |
| Tmax (h) | 0.51 ± 0.02 | 1.50 ± 0.50 |
| AUC0-24 (ng · h/ml) | 493.0 ± 38.7 | 1040.0 ± 232.0 |
| AUC0-∞ (ng · h/ml) | 542.0 ± 46.3 | 1150.0 ± 268.0 |
| t1/2 (h) | 8.27 ± 0.66 | 8.76 ± 1.21 |
| Cltot (ml/min) | 149.0 ± 12.2 | N.A. |
| Cltot/F (ml/min) | N.A. | 2430.0 ± 493.0 |
| Vss (l) | 76.9 ± 8.12 | N.A. |
| Vz/F (l) | N.A. | 1810 ± 214 |
| MRT0-t (h) | 8.59 ± 0.74 | 9.74 ± 1.32 |
| F (%) | N.A. | 7.16 |
N.A., not applicable.