TABLE 3

Inhibition of MRP2-mediated uptake of E217βG by GSH-conjugated catechol metabolites The values shown represent the mean IC50 values ± S.D. obtained from the number of independent experiments shown in parentheses. When experiments were repeated only once, both values are shown.


GSH Conjugate

E217βG Uptake IC50
μM
5-GS-N-Me-α-MeDA 145 ± 46 (3)
2-GS-CA 9.6, 10.2
2-OH-1-GS-E2 2.1 ± 1.0 (3)
2-OH-1-GS-E1 1.6 ± 1.1 (4)
2-OH-4-GS-E2 97, 91
4-OH-2-GS-E2
582 ± 144 (3)