Species | Rate of Metabolism at 30 Min | Extent of Metabolism of Seliciclib | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Met-1 | Met-2 | Met-3 | PMF30-128 | Seliciclib | ||||||
pmol/min/mg | % | |||||||||
Human | 8.49 | 7.89 | 16.1 | 16.4 | 80.9 | 75 | ||||
Monkey | 11.5 | 7.84 | 27 | 33.5 | 122 | 95 | ||||
Rat | 13.1 | 14.2 | 10.6 | 26.1 | 112 | 85 | ||||
Mouse | NQ | NQ | NQ | NQ | <132 | 100 | ||||
Rabbit | 8.36 | 5.8 | 5.43 | 36.1 | 127 | 95 | ||||
Dog | 14.4 | 6.87 | 7.56 | ND | 55 | 70 |
NQ, not quantifiable; ND, not detected