Cytochrome P450 | Substrate | Seliciclib Inhibition IC50 | Positive Control | IC50 |
---|---|---|---|---|
μM | μM | |||
1A2 | 3-Cyano-7-ethoxycoumarin | 67.5 | Furafylline | 3.7 |
2A6 | Coumarin | >150 | Tranylcypromine | 0.7 |
2B6 | 7-Ethoxy-4-trifluoromethyl coumarin | 124 | Tranylcypromine | 8.1 |
2C8 | Dibenzylfluorescein | 119 | Quercetin | 1.6 |
2C9/1 | 7-Methoxy-4-trifluoromethyl coumarin | 3.8 | Sulfaphenazole | 0.26 |
2C19 | 3-Cyano-7-ethoxycoumarin | 19.2 | Tranylcypromine | 0.71 |
2D6/1 | 3-[2-(N,N-diethyl-N-methyl amino) ethyl]-7-methoxy-4-methylcoumarin | 17 | Quinidine | 0.008 |
2E1 | 7-Methoxy-4-trifluoro-methylcoumarin | >150 | Diethyldithiocarbamic acid | 13.6 |
3A4 | 7-Benzyloxy-4-(trifluoromethyl)-coumarin | 3.2 | Ketoconazole | 0.004 |