Silibinin Alone | Silibinin + CsA | |||||
---|---|---|---|---|---|---|
Unconjugated | Total | Unconjugated | Total | |||
Plasma | ||||||
AUC (min mg/ml) | 1.5 ± 0.24 | 19.8 ± 4.9 | 0.2 ± 0.04* | 35 ± 2.8* | ||
t½ (min) | 41 ± 5.4 | 101 ± 11 | 17 ± 4.8* | 398 ± 65* | ||
Cmax (μg/ml) | 92 ± 7 | 89 ± 8.3 | 38 ± 11* | 113 ± 29 | ||
Cl (ml/kg/min) | 90 ± 6.1 | 1.88 ± 0.3 | 340 ± 21 | 0.9 ± 0.1 | ||
Bile | ||||||
AUC (min mg/ml) | 3.1 ± 1.0 | 541 ± 14 | 5.4 ± 1.5 | 306 ± 63* | ||
t½ (min) | 19 ± 3 | 111 ± 41 | 203 ± 17* | 154 ± 23 | ||
Cmax (μg/ml) | 242 ± 55 | 6904 ± 863 | 37 ± 9.1* | 7528 ± 1286 | ||
Tmax (min) | 3 ± 0.98 | 14 ± 4.6 | 4.7 ± 1.8 | 10.7 ± 2.2 | ||
AUCbile/AUCblood | 2.3 ± 0.6 | 31 ± 5.4 | 29 ± 7.9* | 9.7 ± 1.3* |
↵* P < 0.05, significantly different from the 30 mg/kg silibinin alone group