Individual fecal metabolite profiles in humans after a single 200-mg p.o. dose of [14C]1
| Compound | % of Dose | |||||||
|---|---|---|---|---|---|---|---|---|
| Subject 1 | Subject 2 | Subject 3 | Subject 4 | Subject 5 | Subject 6 | Mean | S.D. | |
| 1 | 14.4 | 15.9 | 21.4 | 7.7 | 8.7 | 13.4 | 13.6 | 5.0 |
| U1 | — | — | — | — | — | — | N.A. | N.A. |
| U2 | — | — | — | — | — | — | N.A. | N.A. |
| M1 | 1.8 | 1.9 | 1.6 | 0.5 | 1.0 | 2.5 | 1.6 | 0.7 |
| M2 | — | 0.5 | — | — | 1.0 | — | N.A. | N.A. |
| 2 | 29.3 | 33.4 | 25.4 | 24.9 | 35.2 | 38.0 | 31.0 | 5.4 |
| M4 | 10.6 | 20.2 | 5.9 | 6.0 | 13.3 | 8.8 | 10.8 | 5.4 |
| 3 | 1.3 | — | 1.4 | 0.8 | 1.4 | 1.2 | 1.0 | 0.5 |
| M5 | 1.6 | 2.2 | 1.2 | 2.2 | 3.3 | 5.6 | 2.7 | 1.6 |
| M7 | — | — | — | — | — | — | N.A. | N.A. |
| Sum | 59.0 | 74.1 | 57.0 | 42.1 | 64.0 | 69.5 | 61.0 | 11.2 |
| Dose excreteda | 70.5 | 78.6 | 57.1 | 42.1 | 66.5 | 74.3 | 64.9 | 13.3 |
| 14C profiled (%) | 83.6 | 94.3 | 99.8 | 100.1 | 96.2 | 93.6 | 94.6 | 6.0 |
N.A., not applicable; —, not detected.
↵ a Percentage of dose recovered in feces as reported in Table 1.