Individual circulatory metabolite profiles in humans after a single 200-mg p.o. dose of [14C]1
| Compound | % of Total 14C AUC0-24 | |||||||
|---|---|---|---|---|---|---|---|---|
| Subject 1 | Subject 2 | Subject 3 | Subject 4 | Subject 5 | Subject 6 | Mean | S.D. | |
| 1 | 25.5 | 19.1 | 15.7 | 21.5 | 19.3 | 13.5 | 19.1 | 4.2 |
| U1 | 8.9 | 10.3 | 6.9 | 7.1 | 7.9 | 8.5 | 8.3 | 1.3 |
| U2 | — | 14.5 | 7.5 | 11.1 | 9.5 | 13.5 | 9.4 | 5.2 |
| M1 | — | — | — | — | — | — | N.A. | N.A. |
| M2 | 3.6 | 2.5 | 3.4 | 1.1 | 1.8 | 3.1 | 2.6 | 1.0 |
| 2 | 11.1 | 11.2 | 23.1 | 10.4 | 14.2 | 6.9 | 12.8 | 5.6 |
| M4 | 5.7 | 6.2 | 7.5 | 3.3 | 7.7 | 5.0 | 5.9 | 1.7 |
| 3 | 11.5 | 17.6 | 10.1 | 14.6 | 8.6 | 12.1 | 12.4 | 3.2 |
| M5 | — | — | — | — | — | — | N.A. | N.A. |
| M7 | 1.8 | 1.1 | — | 1.3 | 0.8 | 0.8 | 0.9 | 0.6 |
| 14C profiled (%) | 68.0 | 82.5 | 74.3 | 70.4 | 69.8 | 63.4 | 71.4 | 6.5 |
N.A., not applicable; —, not detected.