Matrix | Time Point | Vanillylamine | Vanillin | 16-HC | 17-HC | 16,17-DHC | Capsaicin | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M | S9 | M | S9 | M | S9 | M | S9 | M | S9 | M | S9 | ||
min | % radioactivity | ||||||||||||
Rat | 0 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 98.4 | 98.8 |
5 | 4.52 | 4.44 | N.D. | N.D. | 21.3 | 7.23 | N.D. | N.D. | 15.4 | 7.17 | 51 | 79 | |
10 | 8.83 | 7.37 | 6.69 | N.D. | 36.6 | 13.8 | 1.56 | N.D. | 18.9 | 11.1 | 21.2 | 63.1 | |
20 | 10.2 | 15.3 | 8.78 | 1.22 | 49.4 | 25.4 | 1.53 | N.D. | 4.65 | 15.5 | N.D. | 35.1 | |
30 | 9.69 | 17.8 | 27.4 | 5.05 | 42.8 | 34.7 | 3.58 | 3.26 | N.D. | 13.2 | N.D. | 16.9 | |
Dog | 0 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 99.3 | 98.9 |
5 | N.D. | N.D. | N.D. | N.D. | 3.1 | N.D. | 1.24 | N.D. | N.D. | N.D. | 90.2 | 96 | |
10 | N.D. | N.D. | N.D. | N.D. | 10.1 | 1.14 | 4.97 | N.D. | 2.91 | N.D. | 75.4 | 92.1 | |
20 | N.D. | N.D. | N.D. | N.D. | 19.7 | 6.48 | 7.92 | 3.87 | 3.93 | N.D. | 56.4 | 77.5 | |
30 | N.D. | N.D. | N.D. | N.D. | 28.3 | 8.21 | 14.2 | 2.21 | 6.05 | 1.41 | 37.7 | 70.2 | |
Human | 0 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 93.2 | 98.5 |
5 | N.D. | N.D. | N.D. | N.D. | 14.2 | 3.21 | 27.4 | 6.42 | 7.95 | 4.04 | 46.9 | 83.6 | |
10 | N.D. | N.D. | 1.36 | N.D. | 19.9 | 6.33 | 42.6 | 12 | 8.81 | 6.84 | 21.7 | 71.7 | |
20 | N.D. | N.D. | 7.9 | N.D. | 23.8 | 13.2 | 54.2 | 25.4 | 4.33 | 12.3 | 4.03 | 44.5 | |
30 | N.D. | N.D. | 10.3 | N.D. | 27 | 20.6 | 55.6 | 31.6 | N.D. | 13.8 | N.D. | 28.1 |
6-HC, 16-hydroxycapsaicin; 17-HC, 17-hydroxycapsaicin; 16,17-DHC, 16,17-dehydrocapsaicin; M, liver microsomes; N.D., not detected.