Control | Probenecid | Sulfanitran | Sulfinpyrazone | |
---|---|---|---|---|
Human MRP2 | ||||
Vmax (pmol/mg/min) | 9683 ± 260 | 11,613 ± 137 | 7685 ± 266 | 11,294 ± 380 |
Km (μM) | 98 ± 4 | 84 ± 2 | 24 ± 2 | 83 ± 7 |
Hill coefficient | 1.60 ± 0.05 | 1.60 ± 0.02 | 1.19 ± 0.08 | 0.96 ± 0.03 |
R2 | 0.9998 | 0.9999 | 0.9977 | 0.9997 |
Mouse Mrp2 | ||||
Vmax (pmol/mg/min) | 2621 ± 64 | 3406 ± 68 | 1971 ± 167 | N.A. |
Km (μM) | 71 ± 3 | 48 ± 2 | 43 ± 10 | N.A. |
Hill coefficient | 1.42 ± 0.05 | 1.11 ± 0.03 | 0.96 ± 0.1 | N.A. |
R2 | 0.9997 | 0.9997 | 0.9953 | N.A. |
N.A., not applicable.