CYP1B1 Variants | N2-OH-PhIP | 4′-OH-PhIP | ||||
---|---|---|---|---|---|---|
Km | Vmax | Kcat | Km | Vmax | Kcat | |
μM | nmol/min/nmol | Vmax/K m | μM | nmol/min/nmol | Vmax/K m | |
Wild-type CYP1B1 | 3.6 | 0.115 | 0.032 | 4.5 | 0.120 | 0.026 |
Trp57Cys | 8.5 | 0.045 | 0.005 | 10.4 | 0.085 | 0.008 |
Gly61Glu | 7.5 | 0.086 | 0.011 | 3.9 | 0.056 | 0.014 |
Arg48Gly/Ala119Ser | 3.2 | 0.057 | 0.018 | 4.1 | 0.049 | 0.012 |
Arg48Gly/Ala119Ser/Leu432Val | 14.8 | 0.153 | 0.010 | 6.0 | 0.100 | 0.017 |
Arg48Gly/Ala119Ser/Leu432Val/Ala443Gly | 30.1 | 0.210 | 0.007 | 2.7 | 0.057 | 0.021 |