Dose and Time | Wild-Type FVB Mice | mdr1a/1b(-/-) Mice | Knockout/Wild-Type Brain/Plasma Ratio | ||||
---|---|---|---|---|---|---|---|
Plasma Concentrations | Brain Concentrations | Average Brain/Plasma Ratio | Plasma Concentrations | Brain Concentrations | Average Brain/Plasma Ratio | ||
ng/ml | ng/g | ng/ml | ng/g | ||||
1 mg/kg | |||||||
0.5 h | 312 (35) | 13.9 (3.7) | 0.04 (0.01) | 429 (16) | 102 (11) | 0.24 (0.03) | 5.53 |
2 h | 68.9 (13.4) | 6.26 (2.62) | 0.09 (0.02) | 76.3 (14.6) | 41.9 (7.9) | 0.56 (0.15) | 6.36 |
10 mg/kg | |||||||
0.5 h | 4559 (745) | 1012 (116) | 0.22 (0.06) | 4916 (314) | 2640 (239) | 0.54 (0.06) | 2.63 |
2 h | 1869 (1502-2235) | 463 (332-594) | 0.25 (0.22-0.27) | 1871 (414) | 1762 (595) | 0.94 (0.20) | 2.86 |