TABLE 5

Predicted ISL parameter values for SUCROSE, PRAZOSIN, and PROPRANOLOL

For each of the three methods, the parameter values listed were combined with the PCP-insensitive parameter values. The resulting ISLs were used to generate the expected outflow profiles in Figs. 5, 6, 7.

ISL Parameter Values	Method 1: Simple Linear Regression		Method 2: FCMA			Method 3: ANN
ISL Parameter Values	PRAZOSIN	PROPRANOLOL	SUCROSE^a	PRAZOSIN	PROPRANOLOL	PRAZOSIN	PROPRANOLOL
ISL2WetLabScaling	5.3	4.1	6.0	3.0	7.0	4.6	2.8
A2BJumpProb	0.35	0.52	0.35	0.37	0.86	0.62	0.75
B2AJumpProb	0.37	0.21^b	0.22	0.40	0.21^b	0.29	0.21^b
B2CJumpProb	0.42^c	0.50^b	0.49	0.41^c	0.50^b	0.50^c	0.50^b
C2BJumpProb	0.56^c	0.31	0.50	0.48^c	0.22	0.42^c	0.32
MetabolizeProb	0.34	0.13^b		0.25	0.12^b	0.19	0.09^b
BindersPerCellMin	6	12		7	6	8	8
BindersPerCellMax	7	14		14	13	15	17
SoluteBindingProb	0.47^c	0.39^b		0.41^c	0.42^b	0.43^c	0.42^b
SoluteBindingCycles	24^c	23^b		23^c	24^b	24^c	23^b
SM values (±1 S.D.)	0.36	0.68		0.50	0.58	0.79	0.97
SM values (±1.5 S.D.)	0.55	0.82		0.77	0.72	0.97	0.98

↵ a The predicted outflow profiles for SUCROSE coadministered with PRAZOSIN and PROPRANOLOL, obtained using these FCMA-predicted parameter values, are provided in Supplemental Fig. S1 along with the predicted sucrose outflow profiles (Fig. S1) when SUCROSE was coadministered with PRAZOSINand PROPRANOLOL.
↵ b The three predicted values of these five propranolol parameters are within 15% of each other.
↵ c The three predicted values of these four prazosin parameters are within 15% of each other.