Noncompartmental pharmacokinetic parameters of 11 test compounds in the African green monkey
All the values represent the mean ± S.D. of each parameter calculated from n = 3 monkeys unless otherwise noted.
| Compound | Half-Life | Mean Residence Time | Clearance | Volume of Distribution |
|---|---|---|---|---|
| min | min | ml/min/kg | l/kg | |
| Ciprofloxacin | 355 ± 49 | 363 ± 66 | 7.35 ± 1.49 | 2.70 ± 0.93 |
| Diclofenac | 94.4 ± 21.4 | 63.2 ± 14.8 | 7.80 ± 1.46 | 1.07 ± 0.35 |
| Erythromycin | 475 ± 124 | 266 ± 44 | 31.6 ± 12.5 | 8.24 ± 2.60 |
| Lidocainea | 117, 139 | 96.5, 139 | 1.62, 2.80 | 0.156, 0.388 |
| Metoprolol | 564 ± 238 | 657 ± 201 | 21.9 ± 11.6 | 14.0 ± 7.1 |
| Moxifloxacin | 245 ± 36 | 341 ± 23 | 21.2 ± 3.1 | 7.27 ± 1.47 |
| Phenytoin | 697 ± 27 | 949 ± 85 | 19.1 ± 6.4 | 19.1 ± 6.1 |
| Prednisone | 193 ± 95 | 280 ± 90 | 7.54 ± 2.00 | 1.99 ± 0.14 |
| Propranolol | 384 ± 187 | 357 ± 192 | 13.1 ± 4.2 | 4.24 ± 1.28 |
| Quinidine | 113 ± 52 | 71.5 ± 21.8 | 41.1 ± 4.4 | 3.00 ± 1.23 |
| Verapamila | 525, 473 | 154, 185 | 7.22, 7.89 | 1.11, 1.46 |
↵ a n = 2 animals only.