Pharmacokinetic parameters of fexofenadine, quinidine, and loperamide after a single oral administration in wild-type and Mdr1-mutated collies The details of pharmacokinetic analyses are described in Materials and Methods. Each value represents the mean ± S.E. of five or six independent experiments. P values were obtained by a two-tailed Student's t test.
Wild Type (n = 5) | Mutant (n = 6) | P Value | |
|---|---|---|---|
| Fexofenadine | |||
| Cmax (ng/ml) | 53.9 ± 13.1 | 90.7 ± 23.1 | 0.224 |
| AUC0–8 (ng·h/ml) | 263 ± 62 | 435 ± 95 | 0.186 |
| AUC0-∞ (ng·h/ml) | 392 ± 77 | 881 ± 249 | 0.118 |
| MRT (h) | 8.21 ± 1.38 | 11.1 ± 1.9 | 0.260 |
| t1/2 (h) | 5.21 ± 0.77 | 6.86 ± 1.35 | 0.343 |
| Quinidine | |||
| Cmax (ng/ml) | 16.5 ± 3.4 | 20.0 ± 7.9 | 0.720 |
| AUC0–8 (ng·h/ml) | 54.5 ± 11.5 | 75.7 ± 21.8 | 0.441 |
| AUC0-∞ (ng·h/ml) | 58.8 ± 12.8 | 89.3 ± 21.8 | 0.284 |
| MRT (h) | 3.17 ± 0.57 | 5.14 ± 0.75 | 0.073 |
| t1/2 (h) | 1.95 ± 0.17 | 2.65 ± 0.36 | 0.136 |
| Loperamide | |||
| Cmax (pg/ml) | 80.8 ± 9.0 | 101 ± 15 | 0.312 |
| AUC0–8 (pg·h/ml) | 467 ± 85 | 556 ± 91 | 0.501 |