BHA-induced mRNA expression profiles in human hepatocytes Hepatocytes were exposed to 100 μM BHA at 37°C for 24 h.
Enzyme | mRNA Expression Level Ratio* (Mean ± S.D.) | ||||
|---|---|---|---|---|---|
| Lot FEP | Lot KCT | Lot ZCA | |||
| HO-1 | 2.59 ± 0.18 | 4.77 ± 0.18 | 2.02 ± 0.25 | ||
| γ-GCS | 0.85 ± 0.12 | 0.89 ± 0.02 | 1.22 ± 0.23 | ||
| UGT1A1 | 2.15 ± 0.16 | 10.31 ± 0.59 | 1.77 ± 0.20 | ||
| CES1 | 1.67 ± 0.35 | 4.49 ± 0.72 | 2.57 ± 0.56 | ||
| NQO1 | 1.97 ± 0.29 | 3.88 ± 0.68 | 1.32 ± 0.30 | ||
| GSTA1 | 1.31 ± 0.17 | 1.46 ± 0.23 | 1.16 ± 0.06 | ||
| GSTP1 | N.D. | N.D. | N.D. | ||
N.D., not determined because of lower mRNA expression levels than the quantification limits
↵* Relative to the vehicle control, n = 3