Cytochrome P450 | Substrates | Inhibitors | Inducers | ||||||
---|---|---|---|---|---|---|---|---|---|
Preferred | Acceptable | Preferred | Acceptable | Preferred | Acceptable | ||||
K m in μM | K m in μM | K i in μM | K i in μM | Recommended concentration in μM | Recommended concentration in μM | ||||
CYP3A4 | Midazolam (1–14) | Nifedipine (5.1–47) | |||||||
Testosterone (52–94) | Dextromethorphan (133–710) | Ketoconazole (0.0037–0.18) | Verapamil (10, 24) | Phenobarbital (100–2000) | |||||
Triazolam (234) | Itraconazole (0.27, 2.3) | Troleandomycin (17) | Rifampin (10–50) | Phenytoin (50) | |||||
Terfenadine (15) | Rifapentine (50) | ||||||||
|
| Erythromycin (33–88) |
|
|
| Dexamethasone (4) |