TABLE 3

Preferred in vivo CYP3A4 probe substrates, inhibitors, and inducers


Cytochrome P450

Substrates

Inhibitors

Inducers
Midazolam Ketoconazole
Buspirone Nefazodone
Felodipine Nelfinavir
Simvastatin Ritonavir
CYP3A4 Lovastatin Saquinavir Rifampin
Eletriptan Telithromycin Carbamazepine
Sildenafil Atazanavir
Triazolam Clarithromycin
Indinavir


Itraconazole

  • Adapted from Food and Drug Administration Guidance for Industry, September 2006