UGT | TSNA | ||||||
---|---|---|---|---|---|---|---|
NNN | NAB | NAT | NNAL | ||||
UGT1A1 | –a | – | – | –b | |||
UGT1A3 | – | – | – | –b | |||
UGT1A4 | + | + | + | +c | |||
UGT1A6 | – | – | – | –b | |||
UGT1A7 | – | – | – | –b | |||
UGT1A8 | – | – | – | –b | |||
UGT1A9 | – | – | – | –b | |||
UGT1A10 | – | – | – | –b | |||
UGT2B4 | – | – | – | –b | |||
UGT2B7 | – | – | – | –b | |||
UGT2B10 | + | + | + | + | |||
UGT2B11 | – | – | – | – | |||
UGT2B15 | – | – | – | –b | |||
UGT2B17 | – | – | – | –d |
↵ a Not detected
↵ b No N-glucuronidation activity was observed against NNAL for the indicated UGTs in previous studies by Wiener et al. (2004a) and d Lazarus et al. (2005)
↵ c UGT1A4 exhibited N-glucuronidation activity against NNAL in previous studies by Wiener et al. (2004a) and in the present study