TABLE 1

N-Glucuronide formation activity of individual UGT-overexpressing HEK293 cell lines against TSNAs


UGT

TSNA

NNN
NAB
NAT
NNAL
UGT1A1 a b
UGT1A3 b
UGT1A4 + + + +c
UGT1A6 b
UGT1A7 b
UGT1A8 b
UGT1A9 b
UGT1A10 b
UGT2B4 b
UGT2B7 b
UGT2B10 + + + +
UGT2B11
UGT2B15 b
UGT2B17



d
  • a Not detected

  • b No N-glucuronidation activity was observed against NNAL for the indicated UGTs in previous studies by Wiener et al. (2004a) and d Lazarus et al. (2005)

  • c UGT1A4 exhibited N-glucuronidation activity against NNAL in previous studies by Wiener et al. (2004a) and in the present study