TABLE 5

Biotransformation of 3 μM M1 into M3 in microsomal preparations (n = 1)

Microsomal Preparation
Biotransformation
%
HLM >90
CLM 35
RLM <
MLM <
CYP2C8 50
Other P450sa
N.D.

  • N.D., not detected

  • ↵ a Tested: CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP2J2, and CYP4F12