TABLE 1
Comparison of the biliary excretion of benzoic substituted isomers7to9and their fully aliphatic counterparts,6bto6d Based on observations in this paper and in McDonagh and Lightner (2007). Rapid biliary excretion means >60% of the injected dose excreted in <2 h with peak excretion <20 min after injection.
Compound | Rapid Biliary Excretion | ||||
|---|---|---|---|---|---|
| Gunn (–UGT1) | Normal (+UGT1) | TR– (–Mrp2) | |||
| No | Yes, as acyl glucuronides | No | ||
| No | No | No | ||
| No | Yes, as acyl glucuronides | No | ||
| Yes | Yes | Yes | ||
| Yes | Yes, unchanged and as acyl glucuronides | No | ||
| Yes | Yes | No | ||