Native Hemoglobin (n = 4) | Native Hemoglobin + Rat Plasma (n = 3) | Cross-Linked Hemoglobin (n = 4) | Cross-Linked Hemoglobin + Rat Plasma (n = 4) | |
---|---|---|---|---|
A (% dose/ml) | 0.087 ± 0.023 | 0.094 ± 0.050 | 0.088 ± 0.020 | 0.108 ± 0.019 |
B (% dose/ml) | 0.58 ± 0.03 | 0.52 ± 0.07 | 0.58 ± 0.02 | 0.56 ± 0.02 |
A (% dose) | 13.0 ± 3.48 | 15.0 ± 6.39 | 13.2 ± 3.05 | 16.3 ± 2.80 |
B (% dose) | 86.4 ± 3.99 | 85.1 ± 6.44 | 86.9 ± 3.26 | 83.9 ± 3.33 |
α (min–1) | 0.61 ± 0.81 | 0.82 ± 0.53 | 0.26 ± 0.13 | 0.36 ± 0.32 |
β (min–1) | 0.00067 ± 0.00026 | 0.00062 ± 0.00042 | 0.00062 ± 0.00015 | 0.00056 ± 0.00004 |
t1/2, β (min) | 1150 ± 390 | 957 ± 261 | 1750 ± 1214 | 1240 ± 85 |
k12 (min–1) | 0.086 ± 0.113 | 0.136 ± 0.1038 | 0.034 ± 0.029 | 0.054 ± 0.039 |
k21 (min–1) | 0.518 ± 0.703 | 0.675 ± 0.443 | 0.207 ± 0.130 | 0.304 ± 0.281 |
k20 (min–1) | 0.0052 ± 0.0023 | 0.0052 ± 0.0041 | 0.0052 ± 0.0021 | 0.0035 ± 0.0007 |
V1 (ml) | 151 ± 1.95 | 167 ± 28.74 | 150 ± 1.01 | 150 ± 1.23 |
V2 (ml) | 29.6 ± 11.41 | 24.5 ± 6.70 | 22.8 ± 5.99 | 30.1 ± 6.64 |
AUC(0→∞) (min/ml) | 916 ± 371 | 689 ± 29 | 1840 ± 737 | 991 ± 82 |
CL (ml · min–1 · g–1) | 0.009 ± 0.002 | 0.010 ± 0.003 | 0.0065 ± 0.0032 | 0.0080 ± 0.0004 |
CLinflux or k12V1 (ml · min–1 · g–1) | 1.15 ± 1.62 | 1.81 ± 1.54 | 0.41 ± 0.38 | 0.64 ± 0.47 |
CLint, met or k20V2 (ml · min–1 · g–1) | 0.0104 ± 0.0028# | 0.0098 ± 0.0068# | 0.0084 ± 0.0014# | 0.0081 ± 0.0004*,# |
CLinflux/CLint, met | 125 ± 192 | 535 ± 782 | 54.8 ± 58.6 | 81.3 ± 63.4 |