TABLE 4

Comparison of total hepatic clearance, volume, and t1/2 from the liver perfusion studies and those in vivo (from Ship et al., 2005 )

Present Perfusion Study (with Rat Plasma)
Data of Ship et. al. (2005)
Ratio (Perfusion/in Vivo)
CLliver
Vperfusion
t1/2
 CLin vivo
Vin vivo
t1/2
 CLliver
V
t1/2
ml · min · g–1 liver ml mn ml · min · g–1 ml/kg mn
Native hemoglobin 0.0109 150 957 0.0366 39–40 (12)a 22–23 0.30 12.5 43.5
Cross-linked hemoglobin
0.0061
150
1240
0.012
9–20 (6)a
33–37
0.51
25
38

  • ↵ a Value within parentheses is volume (ml) for a 300-g rat with a 10-g liver