TABLE 1

Body weight, liver weight normalized for body weight, and bile flow rate in wild-type and transporter gene knockout mice Values are expressed as mean ± S.D.; n = 3 to 4 per group.

Mice	Body Weight	Liver Weight/Body Weight	Bile Flow Rate
	g		μl/min/g liver
Wild-type	27.5 ± 1.4	0.041 ± 0.006	1.3 ± 0.3
Abcc3 ^–/–	27.9 ± 3.1	0.043 ± 0.001	1.3 ± 0.2
Abcc4 ^–/–	26.1 ± 2.4	0.041 ± 0.005	1.3 ± 0.4
Abcc2 ^–/–	29.4 ± 1.9	0.053 ± 0.001^*	0.87 ± 0.02^*
Abcc2^–/–/Abcc3^–/–	27.7 ± 1.5	0.060 ± 0.002^*	0.85 ± 0.15^*

↵* P < 0.05 knockout vs. wild type